Recombinant human epidermal growth factor is a small peptide composed of 53 amino acid residues. It is a member of the EGF-like family. It is a multifunctional growth factor that has a strong pro-division effect on a variety of tissue cells in vitro and in vivo. EGF binds to a specific receptor on the surface of the responding cell. Once bound, it promotes receptor dimerization and phosphorylation at cytoplasmic sites. The activated receptors can bind to at least five proteins with different signal sequences for signal transduction and play a regulatory role in protein synthesis at the translation level.
Recombinant human epidermal growth factor can stimulate various cells of ectoderm and endoderm origin, such as corneal epithelium and endothelial cells, epidermal and dermal cells (such as fibroblasts), mammary acinar and stromal cells, so as to make them proliferate and migrate, accelerate metabolism, and achieve skin rejuvenation.
Recombinant human EGF can promote the biosynthesis of DNA, RNA and functional proteins, promote the synthesis of extracellular macromolecules (such as hyaluronic acid, elastin, etc.), increase skin water content, thereby increasing skin elasticity and moisturizing skin.
Recombinant human epidermal growth factor promotes the active transport of cellular nutrients from the extracellular to the intracellular, increasing the intracellular nutrition. It promotes dermal cells to secrete synthetic collagen fibers, polysaccharides, glycoproteins and other functional molecules, so that the dermal tissue is full and muscle fibers are arranged neatly and tightly, thus reducing and eliminating wrinkles.
It stimulates epidermal cells (including epithelial cells of various tissue origins and various mesenchymal cells) to enter the cell division cycle by binding to EGF receptors, initiating intracellular activation, expression, and secretion of bioactive proteins, etc. of some important functional genes. Therefore, the collagen fibers are arranged in line, and the epidermal cells grow rapidly and regularly and cover the wound surface in time. Obviously it accelerates the wound healing of beauty and cosmetic surgery and other skin wounds, and keep the wound surface smooth, reduce or disappear scars and reduce pigmentation.
EGF has a strong promoting effect on the proliferation of epidermal cells. After the use of EGF, epidermal cells become younger, resulting in less accumulation of pigment and dead cells in the epidermal tissue, so that the skin appears white and flawless, and the abnormal skin manifestations such as stains and pigmentation can be eliminated. The use of recombinant human epidermal growth factor in the treatment and recovery of freckle can effectively prevent the recurrence of freckles.
The recombinant human epidermal growth factor can promote the synthesis of DNA, RNA and hydroxyproline in the process of skin wound tissue repair, induce the transformation of differentiated and mature epidermal cells into epidermal stem cells, accelerate the formation of wound granulation tissue and the proliferation of epithelial cells, thus shortening the healing time of wound and improving the quality of wound repair.
